研究実績／掲載論文
1.
Protein tyrosine phosphatase regulation in fibroblasts from patients with an insulin receptor gene mutation.
Seki N, Yagi S, Suzuki Y, Shimada F, Taira M, Makino H, Amano K, Yagui K, Saito Y, Hashimoto N.
Horm Metab Res. 2008 Dec;40(12):833-7. doi: 10.1055/s-0028-1082082. Epub 2008 Oct 16.
Seki N, Yagi S, Suzuki Y, Shimada F, Taira M, Makino H, Amano K, Yagui K, Saito Y, Hashimoto N.
Horm Metab Res. 2008 Dec;40(12):833-7. doi: 10.1055/s-0028-1082082. Epub 2008 Oct 16.
2.
Regulation of Src homology 2-containing protein tyrosine phosphatase by advanced glycation end products: the role on atherosclerosis in diabetes.
Seki N, Hashimoto N, Taira M, Yagi S, Yoshida Y, Ishikawa K, Suzuki Y, Sano H, Horiuchi S, Yoshida S, Sakurai K, Yagui K, Makino H, Saito Y.
Metabolism. 2007 Nov;56(11):1591-8.
Seki N, Hashimoto N, Taira M, Yagi S, Yoshida Y, Ishikawa K, Suzuki Y, Sano H, Horiuchi S, Yoshida S, Sakurai K, Yagui K, Makino H, Saito Y.
Metabolism. 2007 Nov;56(11):1591-8.
3.
Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice.
Choi YH, Park S, Hockman S, Zmuda-Trzebiatowska E, Svennelid F, Haluzik M, Gavrilova O, Ahmad F, Pepin L, Napolitano M, Taira M, Sundler F, Stenson Holst L, Degerman E, Manganiello VC.
J Clin Invest. 2006 Dec;116(12):3240-51.
Choi YH, Park S, Hockman S, Zmuda-Trzebiatowska E, Svennelid F, Haluzik M, Gavrilova O, Ahmad F, Pepin L, Napolitano M, Taira M, Sundler F, Stenson Holst L, Degerman E, Manganiello VC.
J Clin Invest. 2006 Dec;116(12):3240-51.
4.
Importance of cAMP-response element-binding protein in regulation of expression of the murine cyclic nucleotide phosphodiesterase 3B (Pde3b) gene in differentiating 3T3-L1 preadipocytes.
Liu H, Tang JR, Choi YH, Napolitano M, Hockman S, Taira M, Degerman E, Manganiello VC.
J Biol Chem. 2006 Jul 28;281(30):21096-113. Epub 2006 May 15.
Liu H, Tang JR, Choi YH, Napolitano M, Hockman S, Taira M, Degerman E, Manganiello VC.
J Biol Chem. 2006 Jul 28;281(30):21096-113. Epub 2006 May 15.
5.
Analysis of the insulin-sensitive phosphodiesterase 3B gene in type 2 diabetes.
Sano R, Miki T, Suzuki Y, Shimada F, Taira M, Kanatsuka A, Makino H, Hashimoto N, Saito Y.
Diabetes Res Clin Pract. 2001 Nov;54(2):79-88.
Sano R, Miki T, Suzuki Y, Shimada F, Taira M, Kanatsuka A, Makino H, Hashimoto N, Saito Y.
Diabetes Res Clin Pract. 2001 Nov;54(2):79-88.
6.
Activation of mouse phosphodiesterase 3B gene promoter by adipocyte differentiation in 3T3-L1 cells.
Niiya T, Osawa H, Onuma H, Suzuki Y, Taira M, Yamada K, Makino H.
FEBS Lett. 2001 Sep 7;505(1):136-40.
Niiya T, Osawa H, Onuma H, Suzuki Y, Taira M, Yamada K, Makino H.
FEBS Lett. 2001 Sep 7;505(1):136-40.
7.
Mitogen-activated protein kinase and p70 ribosomal protein S6 kinase are not involved in the insulin-dependent stimulation of cAMP phosphodiesterase kinase in rat adipocytes.
Onuma H, Makino H, Osawa H, Suzuki Y, Taira M, Kanatsuka A, Saito Y.
Biochim Biophys Acta. 1998 Mar 27;1402(2):197-208.
Onuma H, Makino H, Osawa H, Suzuki Y, Taira M, Kanatsuka A, Saito Y.
Biochim Biophys Acta. 1998 Mar 27;1402(2):197-208.
8.
Expression and characterization of deletion recombinants of two cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE-3).
He R, Komas N, Ekholm D, Murata T, Taira M, Hockman S, Degerman E, Manganiello VC.
Cell Biochem Biophys. 1998;29(1-2):89-111.
He R, Komas N, Ekholm D, Murata T, Taira M, Hockman S, Degerman E, Manganiello VC.
Cell Biochem Biophys. 1998;29(1-2):89-111.
9.
Characterization of the cDNA and gene encoding human PDE3B, the cGIP1 isoform of the human cyclic GMP-inhibited cyclic nucleotide phosphodiesterase family.
Miki T, Taira M, Hockman S, Shimada F, Lieman J, Napolitano M, Ward D, Taira M, Makino H, Manganiello VC.
Genomics. 1996 Sep 15;36(3):476-85.
Miki T, Taira M, Hockman S, Shimada F, Lieman J, Napolitano M, Ward D, Taira M, Makino H, Manganiello VC.
Genomics. 1996 Sep 15;36(3):476-85.
10.
Characterization of two recombinant PDE3 (cGMP-inhibited cyclic nucleotide phosphodiesterase) isoforms, RcGIP1 and HcGIP2, expressed in NIH 3006 murine fibroblasts and Sf9 insect cells.
Leroy MJ, Degerman E, Taira M, Murata T, Wang LH, Movsesian MA, Meacci E, Manganiello VC.
Biochemistry. 1996 Aug 6;35(31):10194-202.
Leroy MJ, Degerman E, Taira M, Murata T, Wang LH, Movsesian MA, Meacci E, Manganiello VC.
Biochemistry. 1996 Aug 6;35(31):10194-202.
11.
Differential expression of cGMP-inhibited cyclic nucleotide phosphodiesterases in human hepatoma cell lines.
Murata T, Taira M, Manganiello VC.
FEBS Lett. 1996 Jul 15;390(1):29-33.
Murata T, Taira M, Manganiello VC.
FEBS Lett. 1996 Jul 15;390(1):29-33.
12.
Detection of an amino acid polymorphism in hormone-sensitive lipase in Japanese subjects.
Shimada F, Makino H, Hashimoto N, Iwaoka H, Taira M, Nozaki O, Kanatsuka A, Holm C, Langin D, Saito Y.
Metabolism. 1996 Jul;45(7):862-4.
Shimada F, Makino H, Hashimoto N, Iwaoka H, Taira M, Nozaki O, Kanatsuka A, Holm C, Langin D, Saito Y.
Metabolism. 1996 Jul;45(7):862-4.
13.
Type III cyclic nucleotide phosphodiesterases and insulin action.
Manganiello VC, Degerman E, Taira M, Kono T, Belfrage P.
Curr Top Cell Regul. 1996;34:63-100. Review. No abstract available.
Manganiello VC, Degerman E, Taira M, Kono T, Belfrage P.
Curr Top Cell Regul. 1996;34:63-100. Review. No abstract available.
14.
Insulin stimulates hormone-sensitive cyclic GMP-inhibited cyclic nucleotide phosphodiesterase in rat brown adipose cells.
Omatsu-Kanbe M, Cushman SW, Manganiello VC, Taira M.
FEBS Lett. 1995 Oct 30;374(2):187-91.
Omatsu-Kanbe M, Cushman SW, Manganiello VC, Taira M.
FEBS Lett. 1995 Oct 30;374(2):187-91.
15.
Diversity in cyclic nucleotide phosphodiesterase isoenzyme families.
Manganiello VC, Murata T, Taira M, Belfrage P, Degerman E.
Arch Biochem Biophys. 1995 Sep 10;322(1):1-13. Review. No abstract available.
Manganiello VC, Murata T, Taira M, Belfrage P, Degerman E.
Arch Biochem Biophys. 1995 Sep 10;322(1):1-13. Review. No abstract available.
16.
Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE3 gene family).
Manganiello VC, Taira M, Degerman E, Belfrage P.
Cell Signal. 1995 Jul;7(5):445-55. Review.
Manganiello VC, Taira M, Degerman E, Belfrage P.
Cell Signal. 1995 Jul;7(5):445-55. Review.
17.
Distinctive anatomical patterns of gene expression for cGMP-inhibited cyclic nucleotide phosphodiesterases.
Reinhardt RR, Chin E, Zhou J, Taira M, Murata T, Manganiello VC, Bondy CA.
J Clin Invest. 1995 Apr;95(4):1528-38. Erratum in: J Clin Invest 1997 Feb 1;99(3):551.
Reinhardt RR, Chin E, Zhou J, Taira M, Murata T, Manganiello VC, Bondy CA.
J Clin Invest. 1995 Apr;95(4):1528-38. Erratum in: J Clin Invest 1997 Feb 1;99(3):551.
18.
Insulin resistance associated with decreased levels of insulin-receptor messenger ribonucleic acid: evidence of a de novo mutation in the maternal allele.
Suzuki Y, Hatanaka Y, Taira M, Shimada F, Hashimoto N, Takayanagi M, Taylor SI, Makino H, Yoshida S.
J Clin Endocrinol Metab. 1995 Apr;80(4):1214-20.
Suzuki Y, Hatanaka Y, Taira M, Shimada F, Hashimoto N, Takayanagi M, Taylor SI, Makino H, Yoshida S.
J Clin Endocrinol Metab. 1995 Apr;80(4):1214-20.
19.
Islet amyloid polypeptide and its N-terminal and C-terminal flanking peptides' immunoreactivity in islet amyloid of diabetic patients.
Kanatsuka A, Makino H, Yagui K, Huang CI, Taira M, Mikata A, Yoshida S.
Diabetes Res Clin Pract. 1994 Dec 16;26(2):101-7.
Kanatsuka A, Makino H, Yagui K, Huang CI, Taira M, Mikata A, Yoshida S.
Diabetes Res Clin Pract. 1994 Dec 16;26(2):101-7.
20.
Identification of the phosphorylation site in vitro for cAMP-dependent protein kinase on the rat adipocyte cGMP-inhibited cAMP phosphodiesterase.
Rascón A, Degerman E, Taira M, Meacci E, Smith CJ, Manganiello V, Belfrage P, Tornqvist H.
J Biol Chem. 1994 Apr 22;269(16):11962-6.
Rascón A, Degerman E, Taira M, Meacci E, Smith CJ, Manganiello V, Belfrage P, Tornqvist H.
J Biol Chem. 1994 Apr 22;269(16):11962-6.
21.
Islet amyloid polypeptide gene: no evidence of abnormal promoter region in thirty-five type 2 diabetic patients.
Tokuyama Y, Kanatsuka A, Suzuki Y, Yamaguchi T, Taira M, Makino H, Yoshida S.
Diabetes Res Clin Pract. 1994 Jan;22(2-3):99-105.
Tokuyama Y, Kanatsuka A, Suzuki Y, Yamaguchi T, Taira M, Makino H, Yoshida S.
Diabetes Res Clin Pract. 1994 Jan;22(2-3):99-105.
22.
Molecular cloning of the rat adipocyte hormone-sensitive cyclic GMP-inhibited cyclic nucleotide phosphodiesterase.
Taira M, Hockman SC, Calvo JC, Taira M, Belfrage P, Manganiello VC.
J Biol Chem. 1993 Sep 5;268(25):18573-9.
Taira M, Hockman SC, Calvo JC, Taira M, Belfrage P, Manganiello VC.
J Biol Chem. 1993 Sep 5;268(25):18573-9.
23.
A glycine-1008 to valine mutation in the insulin receptor in a woman with type A insulin resistance.
Nozaki O, Suzuki Y, Shimada F, Hashimoto N, Taira M, Hatanaka Y, Notoya Y, Kanashiro O, Makino H, Yoshida S.
J Clin Endocrinol Metab. 1993 Jul;77(1):169-72.
Nozaki O, Suzuki Y, Shimada F, Hashimoto N, Taira M, Hatanaka Y, Notoya Y, Kanashiro O, Makino H, Yoshida S.
J Clin Endocrinol Metab. 1993 Jul;77(1):169-72.
24.
Type 2 (non-insulin-dependent) diabetes mellitus associated with a mutation of the glucokinase gene in a Japanese family.
Shimada F, Makino H, Hashimoto N, Taira M, Seino S, Bell GI, Kanatsuka A, Yoshida S.
Diabetologia. 1993 May;36(5):433-7.
Shimada F, Makino H, Hashimoto N, Taira M, Seino S, Bell GI, Kanatsuka A, Yoshida S.
Diabetologia. 1993 May;36(5):433-7.
25.
Abnormal messenger ribonucleic acid (mRNA) transcribed from a mutant insulin receptor gene in a patient with type A insulin resistance.
Shimada F, Suzuki Y, Taira M, Hashimoto N, Nozaki O, Makino H, Yoshida S.
Diabetologia. 1992 Jul;35(7):639-44.
Shimada F, Suzuki Y, Taira M, Hashimoto N, Nozaki O, Makino H, Yoshida S.
Diabetologia. 1992 Jul;35(7):639-44.
26.
Insulin receptor gene mutation: a molecular genetical and functional analysis.
Makino H, Taira M, Shimada F, Hashimoto N, Suzuki Y, Nozaki O, Hatanaka Y, Yoshida S.
Cell Signal. 1992 Jul;4(4):351-63. Review. No abstract available.
Makino H, Taira M, Shimada F, Hashimoto N, Suzuki Y, Nozaki O, Hatanaka Y, Yoshida S.
Cell Signal. 1992 Jul;4(4):351-63. Review. No abstract available.
27.
Molecular cloning and expression of human myocardial cGMP-inhibited cAMP phosphodiesterase.
Meacci E, Taira M, Moos M Jr, Smith CJ, Movsesian MA, Degerman E, Belfrage P, Manganiello V.
Proc Natl Acad Sci U S A. 1992 May 1;89(9):3721-5.
Meacci E, Taira M, Moos M Jr, Smith CJ, Movsesian MA, Degerman E, Belfrage P, Manganiello V.
Proc Natl Acad Sci U S A. 1992 May 1;89(9):3721-5.
28.
Defects in insulin binding and receptor kinase in cells from a woman with type A insulin resistance and from her family.
Suzuki Y, Hashimoto N, Shimada F, Taira M, Mimura M, Nozaki O, Tawata M, Onaya T, Makino H, Yoshida S.
Diabetologia. 1991 Feb;34(2):86-92.
Suzuki Y, Hashimoto N, Shimada F, Taira M, Mimura M, Nozaki O, Tawata M, Onaya T, Makino H, Yoshida S.
Diabetologia. 1991 Feb;34(2):86-92.
29.
Comparison of putative cGMP-binding regions in bovine brain and cardiac cGMP-stimulated phosphodiesterases.
Tanaka T, Hockman S, Moos M Jr, Taira M, Meacci E, Murashima S, Manganiello VC.
Second Messengers Phosphoproteins. 1991;13(2-3):87-98.
Tanaka T, Hockman S, Moos M Jr, Taira M, Meacci E, Murashima S, Manganiello VC.
Second Messengers Phosphoproteins. 1991;13(2-3):87-98.
30.
Insulin-resistant diabetes associated with partial deletion of insulin-receptor gene.
Shimada F, Taira M, Suzuki Y, Hashimoto N, Nozaki O, Taira M, Tatibana M, Ebina Y, Tawata M, Onaya T, et al.
Lancet. 1990 May 19;335(8699):1179-81.
Shimada F, Taira M, Suzuki Y, Hashimoto N, Nozaki O, Taira M, Tatibana M, Ebina Y, Tawata M, Onaya T, et al.
Lancet. 1990 May 19;335(8699):1179-81.
31.
[Molecular genetics of insulin receptor and its disorder].
Makino H, Taira M, Hashimoto N, Shimada F, Suzuki Y, Yoshida S, Ebina Y.
Nihon Rinsho. 1989 Oct;47(10):2299-304. Japanese. No abstract available.
Makino H, Taira M, Hashimoto N, Shimada F, Suzuki Y, Yoshida S, Ebina Y.
Nihon Rinsho. 1989 Oct;47(10):2299-304. Japanese. No abstract available.
32.
Human diabetes associated with a deletion of the tyrosine kinase domain of the insulin receptor.
Taira M, Taira M, Hashimoto N, Shimada F, Suzuki Y, Kanatsuka A, Nakamura F, Ebina Y, Tatibana M, Makino H, et al.
Science. 1989 Jul 7;245(4913):63-6.
Taira M, Taira M, Hashimoto N, Shimada F, Suzuki Y, Kanatsuka A, Nakamura F, Ebina Y, Tatibana M, Makino H, et al.
Science. 1989 Jul 7;245(4913):63-6.
33.
Familial type C syndrome of insulin resistance and short stature with possible autosomal dominant transmission.
Nakamura F, Taira M, Hashimoto N, Makino H, Sasaki N.
Endocrinol Jpn. 1989 Jun;36(3):349-58.
Nakamura F, Taira M, Hashimoto N, Makino H, Sasaki N.
Endocrinol Jpn. 1989 Jun;36(3):349-58.
34.
First-phase insulin response to glucose in nonobese or obese subjects with glucose intolerance: analysis by C-peptide secretion rate.
Kanatsuka A, Makino H, Sakurada M, Hashimoto N, Iwaoka H, Yamaguchi T, Taira M, Yoshida S, Yoshida A.
Metabolism. 1988 Sep;37(9):878-84.
Kanatsuka A, Makino H, Sakurada M, Hashimoto N, Iwaoka H, Yamaguchi T, Taira M, Yoshida S, Yoshida A.
Metabolism. 1988 Sep;37(9):878-84.
35.
Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.
Ebina Y, Araki E, Taira M, Shimada F, Mori M, Craik CS, Siddle K, Pierce SB, Roth RA, Rutter WJ.
Proc Natl Acad Sci U S A. 1987 Feb;84(3):704-8.
Ebina Y, Araki E, Taira M, Shimada F, Mori M, Craik CS, Siddle K, Pierce SB, Roth RA, Rutter WJ.
Proc Natl Acad Sci U S A. 1987 Feb;84(3):704-8.