(Fig.1) Quantum mechanical fictitious models with No realistic figures are inapplicable to useful technology and medicine that need to use real atomic model with actual shapes as tools to build practical molecular devices.
(Fig.D) Quantum mechanical only mainstream approximation = density functional theory (= DFT ) stops all the applied science.
The impractical one-pseudo-electron DFT approximation is used in all the present fields such as metal, semiconductor, insulator, molecule, chemistry, biology, which hampers scientific development.
(Fig.B) Biological, medical researches without looking into real atomic interaction are just waste of time, which cannot cure deadly diseases.
All the current biological and medical researches are completely irrelevant to the (useless) quantum mechanics ( so-called quantum biology has nothing to do with actual biology, this p.30-10.conclusion, this-lower-looking ahead ).
This 4. Biologists' views says
"Many biologists consider physical laws, artificial life, robotics, and even theoretical biology as largely irrelevant for their research.
biologists, when they have the facts, need not worry about physical theories that neither address nor alter their facts."
This-middle-quantum biology today says
"Despite the work of Schrödinger and other pioneers of quantum mechanics, physicists of the 20th century believed that quantum effects had No significant impact on biology.
There is no doubt that quantum biology is still in infancy."
Today's biological and medical research unable to utilize detailed atomic mechanism due to the impractical quantum mechanics is why finding cures for deadly cancers, Alzheimer HIV is still impossible despite the incredibly longtime research.
Actually, today's biological (or medical ) researches ( this p.8-Methods, this p.2~3-Materials and Methods ) do Not use (useless) quantum mechanical methods (= No Schrodinger equation, DFT nor MD was used ) nor consider detailed atomic interaction (= so clarifiying diseases' atomic mechanism or curing cancers is impossible ).
All the current biological tools are based on enzymes, virus plasmid vectors and antibodies obtained from natural organisms such as bacteria, viruses and immunized animals, which tools are Not designed nor created by humans or (useless) quantum mechanics.
Due to the impractical quantum mechanics, DFT and molecular dynamics, biological and medical researchers are unable to see and utilize atomic interaction.
↑ It means the current biological and medical researches unable to see atomic interactions have to adopt the extremely time consuming trial and error approach to vaguely see what proteins can bind to each other using immunofluorescence, Western blotting based on antibodies (= antibodies are the biology's only tool to vaguely investigate protein interaction ) obtained from immunizing natural animals Not from (useless) quantum mechanical calculations
↑ The detailed (atomic) interaction mechanism between antibodies and proteins is unclear, which means predicting protein behavior and drug development are impossible in the current biological and medical researches.
In biological methods such as constructing recombinant DNAs, they just amplify target DNAs ( originating from natural organisms' genes ) by PCR based on natural bacterial enzymes, insert those amplified DNAs into (natural) viral plasmid DNA vectors by bacterial enzymes such as restriction enzymes and ligase, transfect it into cultured (bacterial) cells which eventually produce the target proteins that can be detected by immunofluorescence based on natural-animal's antibodies.
↑ No atomic interaction nor (useless) quantum mechanics is used in biological and medical researches.
To discover some 'lucky drugs', medical researchers have to take extremely much time in (blindly) trying various drug candidate molecules out of almost infinite choices, without looking into detailed atomic interactions.
It is impossible for this macroscopic trial-and-error approach without considering precise atomic interactions to accidentally find some molecule or drugs effective against deadly cancers.
↑ To design and build molecular devices or enzymes to kill cancers without side effect, precisely knowing and manipulating each atom and molecule are indispensable (= for this, knowing each realistic atomic shape is necessary ).
This wide gap between the current medical research and underlying atomic physics is why many deadly diseases such as cancers and Alzheimer are still incurable despite extremely longtime researches, a lot of money and researchers' lives wasted for them.
Despite a huge amount of money and time wasted, cancers are still incurable, which means these research papers published in academic journals are unable to lead us into curing these deadly diseases.
↑ But academic journals demand that researchers should always waste a lot of time in citing and following even these old useless papers only to keep journals' high impact factors instead of allowing them to try really useful new technology (= independent of old papers and methods that will reduce journals' impact factors ), which old bad habit prevents effective treatment of cancers and other deadly diseases.
The present biological and medical researches do Not use detailed atomic interactions due to the impractical basic physics or quantum mechanics.
This inability to clarify detailed atomic interaction in the current medical research is why deadly cancers and Alzheimer are still incurable.
For example, the recent cancer research paper ↓
p.8-Method-left says (natural) animals and incubation of cancer tissues and cells.
p.8-right says antibodies (= obtained by immunizing natural animals ).
p.8-right Prime editing used plasmid DNA vectors, PCR. ligation, E.coli, all of which came from natural organisms such as bacteria, Not from creation by humans nor (useless) quantum mechanics.
p.9-left-Natural comet assays just conducted electrophoresis of the whole DNA samples without looking into individual atoms.
p.9-left HR and NHEJ reporter assays used flow cytometry based on antibodies (= obtained from immunizing natural animals ) and GFP obtained from jellyfish.
p.9-left-4~5th-paragraphs mention observation by the fluorescence microscope (= without looking into individual atoms ) based on immunofluorescence using antibodies obtained from immunizing natural animals.
p.9-right-3~last-paragraphs used antibodies and LC-MS/MS = liquid chromatography mass spectrometry which vaguely separated the whole peptide samples based on their sizes and ions without looking into individual atomic interaction.
p.10 also used this LC-MS/MS without using (useless) quantum mechanical methods.
The 6th paragraph of this recent biological research news says
"The researchers modified stem cells (= knock out the gene of stem cells related to DNA replication by CRISPR-Cas9 ) to divide only if they are supplemented with thymidine, one of the building blocks of DNA. The cells that have been subjected to this safety treatment cannot replicate their genome without the supplementary component vital for DNA synthesis. This precludes their proliferation. When the cells are differentiated for their various tasks, they cease to divide and no longer require the supplement"
↑ So this biological or medical research just deleted (= knocked out ) the gene of thiymidylate synthase (= TYMS ) of stem cells by bacterial CRISPR-Cas-9, which could not produce thymidine nor synthesize DNA without being supplemented with thymidine.
↑ That's all. No (useless) quantum mechanics (= Schrodinger equation, DFT.. ) was used, and No detailed atomic interaction was considered in this research.
Hence, the detailed biological mechanism remained unknown, and No effective medical treatment could be developed.
↑ This research paper ( this ↓ ).
p.1-abstract says nothing about this research having practical use (= so useless research for therapy ).
p.3-1st-paragraph says "Using CRISPR-Cas9 (= derived from natural bacterial immunity, Not from quantum mechanics nor being created by humans ), we genetically inactivated thymidylate synthase (TYMS), the only known enzyme in charge of the de novo thymidylate (dTMP) synthesis"
↑ The same research paper's materials and methods ↓
p.14 used cells and genome editing by bacterial CRISPR-Cas-9
p.16 used flow cytometry based on antibodies derived from immunizing (natural) animals.
p.17-1st-paragraph used ELISA based on antibodies derived from immunizing (natural) animals.
p.18 used Immunocytochemistry, immunohistochemistry based on antibodies derived from immunizing natural animals (= Not from quantum mechanics ).
p.19 used PCR based on (natural) bacterial enzymes and a rabbit polyclonal primary antibody.
↑ The current biological or medical researches do Not use (useless) quantum mechanics nor consider the microscopic atomic interaction, which is why effective drug development is impossible.
The current deadend biological and medical science (= due to impractical quantum mechanics) keeping deadly cancers incurable is masked by an incredible amount of overhyped news that falsely raises patients' expectation and prevents developing truly-effective treatments.
No matter how many times we see the hyped bright news on cancer immunotherapy researches published in journals, the immunotherapy is still ineffective against almost all deadly cancers. ← No progress, and we should give up those hopeless single-pattern immunotherapies especially against solid cancers.
For example, the first paragraph of this hyped news says
"Enormous additions to our knowledge of human biology at the molecular and genetic level have opened the door to a potential (= which means still useless ) “golden age” of cancer treatment."
Abstract of this hyped journal says
"Nanotechnology provides a promising platform for improving cancer detection and treatment in the future (= just speculation, still useless now ), but further research is needed to overcome the current limitations in clinical translation."
The 18th paragraph of this dubious quantum-hype news says
"How it is possible that thought processes are dictated by quantum rules? Is our brain working like a quantum computer ? No one yet knows the answers (= which means quantum mechanics has been useless for explaining biological mechanism ), but the empirical data strongly appears (= just baseless speculation ) to suggest that our thoughts follow quantum rules."
The last paragraph of this hyped news says
"This research has shown the possibilities (= just speculation ) presented by quantum therapeutics as a new technology to communicate with biology. The fusion of quantum bioelectronics and medicine brings us one step closer to (= still unrealized ) a new treatment paradigm for disease (← ? )"
↑ This research claims some applied electric field (causing quantum tunneling ? ) might trigger apoptosis of some cancer cells.
↑ But this research ( this p.10-methods-p.13 ) did Not look into any detailed atomic interaction of apoptosis, nor use (useless) quantum mechanical calculations such as Schrödinger equation, density functional theory (= DFT ) or molecular dynamics (= MD ), which means this cancer research is macroscopic trial-and-error approach taking too much time to find "lucky" treatment (= so curing cancers is hopeless ).
The last paragraph of another hyped news says
"The study opens up a new avenue (= ambiguous ) of opportunity to develop drugs that can attack significant diseases such as cancer, fibrosis, and other aging-related conditions. The team is now looking ahead to further research and potential clinical trials (= still unrealized ), representing a promising advancement in the quest for healthier aging (← ? )"
↑ This research ( this p.18-23 ) also did Not consider any detailed atomic interaction, instead, they only looked into macroscopic cells, mice, proteins using immunofluorecence (= IF ), immuno blotting based on natural-animal-based antibodies, and dealt with DNA, RNA using natural-organism-based enzymes with No (useless) quantum mechanical calculation.
The 2nd-last paragraph of this hyped news says
"The researchers hope these findings will (= just speculative future, still useless ) help scientists develop better diagnostic and therapeutic approaches for breast cancer brain metastasis patients."
↑ This research ( this p.24-28 ) also did Not consider atomic interactions, instead, they only looked at macroscopic cells, DNA proteins using immuno-blotting by natural-animal-based antibodies and natural-organism-based enzymes with No quantum mechanical calculation.
↑ The current biological and medical researches do Not look into detailed atomic interaction, hence, developing effective drugs by precisely understanding detailed atomic interaction between drugs and cancer cells is impossible. → cancer is incurable
The 4th, 7th, 8th, last paragraphs of this hyped news say
"they discovered that stress (= confine a mouse in very small tube ) causes certain white blood cells called neutrophils to form sticky web-like structures that make body tissues more susceptible to metastasis."
"The team found that stress hormones called glucocorticoids acted on the neutrophils. These stressed neutrophils formed spider-web-like structures called NETs (neutrophil extracellular traps). NETs form when neutrophils expel DNA. Normally, they can defend us against invading microorganisms. However, in cancer, NETs create a metastasis-friendly environment (= NET is double-edged sword )."
"First, she removed neutrophils from the mice using antibodies (= unrealistic treatment ). Next, she injected a NET-destroying drug (= DNase I enzyme ) into the animals. Lastly, she used mice whose neutrophils couldn't respond to glucocorticoids (= glucocorticoid-receptor-gene-deficient mice, which gene-deletion cannot be used for human's treatment ). Each test achieved similar results. The stressed mice no longer developed more metastasis (= NET and glucocorticoid could exacerbate metastasis )"
"The team also speculates that future drugs (= just speculation, still useless research ) preventing NET formation could benefit patients whose cancer hasn't yet metastasized"
↑ This research claims some cancer metastasis was reduced by suppressing the activity of neutrophil extracellular traps (= NET ) using knockout mice with abnormal gene of glucocorticoid receptor (= GR ) which receptor is needed for formation of NET, and injecting the enzyme DNase I that may destroy NET ( this summary ).
This research did Not consider any atomic interaction nor (useless) quantum mechanics (= detailed protein-enzymatic reaction mechanism at atomic level remains unclear ).
First of all, this neutrophil extracellular trap (= NET ), which is said to cause cancer metastasis, is necessary for our immune system protecting us from infection.
This 5.conclusion-2nd-paragraph says
"it should be noted that neutrophils and NETs are important components of innate immunity, and inhibition of NET formation or destruction of formed NETs may affect neutrophils and reduce pathogenic clearance" ← severe side effect caused by targeting NET
In order to prevent cancer metastasis, this research also tried to suppress the stress hormone glucocorticoids ( this p.1-in brief, p.8(or p.7)-right-1st-paragraph says loss of GR = glucocorticoid receptor in neutrophils did Not affect the primary tumor, but it abrogated stress-induced lung metastasis ). ← Primary cancers are still incurable in this research method.
But this glucocorticoid hormones are also necessary for our cells' growth, metabolism and anti-inflammatory function.
The current cancer researches try to sacrifice these humans' normal proteins and hormones that are essential for us to survive. ← These cancer treatments sacrificing normal neutrophil-immune system and glucocorticoid hormones are likely to cause unrealistically-damaging side effects.
To develop effective cancer treatments without sacrificing normal cells' functions, we need to clarify detailed atomic mechanism and interaction, and create artificial proteins or molecular nano-device that can effectively eliminate only harmful cancer cells by precisely distinguishing them from normal cells (= at the atomic level ).
But the current mainstream quantum mechanics has been unrealistic and useless, which prevents medical researchers from using practical atomic models to find effective drugs or treatments.
This research also used the natural enzyme called DNase I (= protein discovered a long time ago ) to destroy neutrophil extracellular trap (= NET, this summary ), which could increase the chance of infection ( this-introduction-2nd-paragraph ).
And cancer cells are known to inhibit DNase I ( this-abstract ). DNase activity is known to be too short to use for cancer treatment ( this 4.Targeting neutrophils-6th-paragrah says DNase I has a relatively short-half and is quickly inactivated by G actin proteins, for therapeutic window of DNase I is small ).
The impractical quantum mechanical atomic theory has prevented biological and medical researches from considering atomic interactions essential for understanding cancer formation and finding effective drugs.
All the current biotechnology or medical research tools depend on enzymes, DNAs, plasmids originating from natural organisms, which were Not designed by humans nor (useless) quantum mechanical theory ( this-lower-method used No quantum mechanics ).
This research methods ↓
p.19 Knockout mice with glucocorticoid receptor (= GR ) deficiency in neutrophils.
p.22 Flow cytometry for cell separation and distinction by using antibodies obtained from immunizing natural animals by the target protein antigens
p.23 immunofluorescence staining using antibodies (from animals ).
p.24 in vitro T cell activation assay by using flow cytometry antibodies.
p.24 real-time PCR using bacterial polymerase enzymes.
p.24 Western blot and cytokine array using antibodies obtained from immunizing animals.
p.25 ELISA used antibodies obtained from animals.
p.25 CRISPR/Cas9 originated from bacterial immune system.
p.25 RNA sequencing using natural enzymes.
p.26 ChIP means chromatin-immunoprecipitation using antibodies obtained from animals.
↑ As a result, the current biological or medical researches completely ignoring detailed atomic interactions due to useless mainstream quantum mechanics are unable to develop effective treatments or reduce severe side effects forever. ← Researchers just waste their time and ruin their careers as slaves to journals.
(Fig.J) Academic journals can Not cure cancer nor build practical quantum computer ! Their useless pseudo-science (= fictional quasiparticle, black hole, BigBang.. ) ruins researchers' careers and future.
Due to the stalled mainstream atomic physics or (fictional) quantum mechanics, all the current researchers in biology, medicine and physics only aim to publish papers as slaves to academic journals instead of really aiming to cure cancers or invent useful nano-devices.
So researchers are just wasting their precious time and (taxpayers') money in publishing papers on impractical science in academic journals, ruining their careers and future.
Examples of useless pseudo-science researches intended only for publishing papers are fictional quasiparticles like this, this, this, pseudospin, extra-dimension, black hole..
Other impractical researches are this, this, this, this.
Academic journals are trying to exploit their (empty) prestige to manipulate the world's researchers in corporations and universities, let them spread overhyped (useless) science news, which just benefits academic journals by sacrificing researchers' lives, future, and corporations' (or taxpayers' ) money.
Actually, Google just lost a significant amount of money in fruitless AI Deepmind, Alphafold and impractical quantum computer's research only to obtain the honor of publishing papers in top journals (= this means Google spreading overhyped quantum computer and AI news is also one of victims exploited by top journals ).
No matter how many times researchers published their papers in prestigious (top) journals, many deadly diseases such as cancers and Alzheimer are still incurable, and quantum computers are hopeless, impractical forever.
Academic journals always forced scientists to use and reference old impractical (obsolete) physical models to explain observed phenomena as the necessary condition for publishing papers, which bad old customs of automatically referencing old fictitious useless theories can keep journals' high impact factor by sacrificing really-useful scientific development, researchers' careers, future, and preventing curing deadly diseases.
↑ When the physics, biological and medical papers on (still-)useless research are published in (top) journals, researchers are required to cite these useless old papers only to contribute to journals' high impact factor. → Technological innovation stalls stuck in old deadend methodology, No effective drug discovery.
Professors in universities got their academic positions by publishing their papers in (top) journals, so they tend to force young researchers and students to prioritize publishing papers in academic journals instead of doing really-useful researches, which old bad habit and their pseudo-science will ruin the researchers' careers and just end up raising university's tuition tormenting students and taxpayers.
It is urgent that we stop blindly worshiping top journals' pseudo-science religion that just ruins researchers' careers, delays developing really-useful devices, prevents curing cancers, and kills patients.
See this
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