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Quantum computer is useless
(Fig.1) Classical computer is used instead of useless quantum computer.
Insider Brief of this hyped fake news (10/14/2025) says
"IonQ demonstrated a new quantum-classical algorithm that accurately computes atomic-level forces, marking progress in applying quantum computing to complex chemical systems." ← fake news
"The QC-AFQMC (= quantum-classical auxillary-field quantum Monte Carlo ) algorithm, developed with a Global 1000 automotive partner, achieved higher accuracy than classical methods and enables modeling of materials for efficient carbon capture." ← fake quantum advantage.
↑ This research paper (= this-1st-paragraph-link ) ↓
p.9-2nd-last paragraph says
"The accuracy and efficiency of AFQMC calculations critically depend on the quality of
the trial wave function" ← Useless quantum mechanics just choosing fake trial wavefunctions for unsolvable Schrödinger equations.
p.26-1st-paragraph says
"The quantum computational components of the QC-AFQMC calculations described herein
were performed using classical simulators provided by the Qiskit framework... they were Not executed
on physical quantum hardware" ← No quantum computers were used after all.
↑ So this research used only classical computers disguised as "quantum simulators" contrary to the above overhyped fake news.
(Fig.2) Quantum computers and mechanics are useless.
This or this-overhyped IonQ's flagship drug development ↓
1st-paragraph says -- Fake drug development
"hybrid quantum- and GPU-accelerated workflow (= "hybrid" is just a classical computer ) to model a critical step in a nickel-catalyzed synthetic chemical reaction, a key process relevant to drug development"
17th-paragraph says -- Classical computer needed
"Our innovative approach, based on the Quantum-Classical Auxiliary-Field Quantum Monte Carlo (QC-AFQMC) algorithm, is one of our frontrunners in this initiative"
22th-paragraph says -- Choose trial wavefunction
"Trial State Preparation: .. initial state (an approximation of the system's ground state), and this trial state was further optimized using a Variational Quantum Eigensolver (VQE = hybrid classical method )." ← Fake atomic trial wavefunctions must be chosen for unsolvable Schrodinger equation that cannot predict anything
23th-paragraph says -- No quantum computation
"The trial wave function was repeatedly prepared and measured on IonQ Forte" ← IonQ's useless quantum computer (= Forte ) could only "measure (= sampling )" their qubits that represented the artificially-chosen trial wavefunctions without quantum computation
25th-paragraph says -- Classical computer calculated energy
"Wave function overlaps and ground-state energies were computed using efficient matrix operations. These computations were accelerated using NVIDIA GPUs (= classical computers ), leveraging classical resources to handle the post-processing" ↓
↑ In this QC-AFQMC method, first, they have to artificially choose fake trial wavefunctions for unsolvable Schrodinger equations in the impractical quantum variational method or VQE, whose energy was calculated by a classical comptuer.
IonQ used just 16 qubits (= one qubit takes only 0 or 1 value, so still Not a quantum computer ) to represent those chosen (simplified) atomic trial wavefunctions ( this or this-3rd-paragraph ).
Quantum computers are impractical forever, too error-prone to calculate anything, cannot factor even 21, much less calculate molecular energy. ↓
So in this useless QC-AFQMC method, IonQ's just 16 qubits were used to express those chosen (simplified) trial wavefunctions which were measured for a classical computer to recover the original chosen trial wavefunction.
↑ This or this-p.9 shows a quantum computer (= QPU ) just "measured" qubits (= representing chosen trial wavefunction or circuit prepared by a classical computer ), and classical computers CPU, GPU must calculate all atomic energies (= including post-process ) instead of the useless quantum computers.
In this or this-p.2-Fig.1c on QC-AFQMC, quantum processor's qubits that represented the chosen trial wavefunction were sampled by classical computer-updated gate parameters called "overlap". ← Quantum computer (= processor ) did No computation.
Calculating molecular energy from the chosen trial wavefunction must be conducted by a classical computer instead of the error-prone useless quantum computers. ↓
Choosing fake trial wavefunction for unsolvable Schrodinger equation means quantum mechanics is useless, cannot predict any molecular energy, much less predict drugs.
This-p.9-2nd-last-paragraph says -- Trial wavefunction matters
"The accuracy and efficiency of AFQMC calculations critically depend on the quality of
the trial wave function"
This and this-p.2-upper-5. says -- Wrong trial wavefunction
"Since you must preprogram your quantum trial wavefunction, you could never prepare the
exact trial wave function without knowing it ahead of time, meaning that your algorithm would
never be exact (= in quantum mechanics and this IonQ's QC-AFQMC method )"
And the quantum computers, which cannot calculate anything, are meaningless and unnecessary in this process of molecular energy calculation or QC-AFQMC method, because they just need to calculate energy directly from chosen trial wavefunctions Not through the quantum computer's (= QPU ) meaningless measurement ( this or this-p.9 ). ↓
This or this on QC-AFQMC paper's review ↓
p.5-2nd-paragraph says -- Classical computer calculated everything
"there is
nothing surprising or a breakthrough in these results. The heavy lifting remains on the classical
computing side"
p.14-2nd-paragraph says -- Classical computer's trial wavefunction
"The trial wavefunctions used in our experiments involve
parameters that were pre-optimized classically" ← The chosen trial wavefunction's energy was calculated by a classical computer before it was transferred to the useless quantum computer. ↓
This overhyped IonQ's QC-AFQMC paper ↓
p.4-2nd-paragraph says -- Quantum DFT, CCSD failed
"DFT and even the coupled cluster singles and doubles with
perturbative triples [CCSD(T)], which is regarded as the gold standard in terms of accuracy, are not able to reliably model these systems."
p.5-last-paragraph says -- Classical computer matters
"The core innovation in QC-AFQMC is not simply its hybrid structure, but the way it divides tasks: the quantum computer prepares the correlated trial state and performs shadow
tomography measurements, after which all imaginary time propagation and observable
estimation are carried out on the classical computer."
p.7-Fig.1 says
"the nickel-catalyzed deformylative
Suzuki–Miyaura cross-coupling reaction. Our work focuses on modeling the oxidative
addition step denoted B → [B-C] → C"
p.12-D. QC-AFQMC says -- Wrong trial wavefunction
"if the trial state is the exact ground state,
then the weight factor is no longer an approximation, and the predicted energy is also exact. On the other hand, if the trial state is a poor approximation to the ground state, it will
introduce a significant bias to the predicted energy"
p.14-last-paragraph says
"we first
prepare a trial state |ΨT ⟩ via VQE (= from artificially-chosen trial wavefunctions that cannot predict anything )"
p.19-1st-paragraph says -- Only a few orbits calculated
"the most common option is to reduce the system to an active space. Since the
active space only contains a fraction of the orbitals in the full space, it becomes feasible to
prepare its wavefunction on today’s quantum computers"
p.21-c. says -- No quantum computation
"Next, the trial state is sampled using matchgate shadows on a
quantum computer." ← The useless quantum computer could only sample or measure qubits parametrized by the artificially-chosen trial wavefunction
p.21-d says -- Classical computer calculated energy
"All electronic structure calculations were performed using the PySCF framework (= classical computer ).. for (useless) density functional theory evaluations"
p.26-1st-paragraph says -- Classical beats quantum
"parameter optimizations on quantum computers is also very challenging.
Fortunately, there are methods to obtain the optimal or close-to-optimal ansatz (= chosen trial wavefunction )
parameters classically"
p.39-last says -- Only 8 orbits chosen
"Projecting this to a 16-qubit system (an 8-electron, 8-orbital active space)" ↓
↑ So IonQ just artificially chose fake trial wavefunctions for some molecular 8 orbitals (= other orbitals were ignored due to taking too much time ), and parameterized this chosen trial wavefunction expressed in only 16 ion qubits, whose energy was calculated by a classical computer.
↑ No quantum computation nor quantum mechanical prediction, so No drug discovery contrary to hypes.
This or this news on useless quantum chemistry drug discovery (2026) ↓
2nd-paragraph says -- Classical computer needed
"The demonstration modeled the heme active site of cytochrome P450nor, a nitric oxide reductase.. By pairing GPU-accelerated classical pre-processing in Promethium with quantum measurements on IonQ Forte, the workflow calculated electrostatic interaction energy within 0.5 kcal/mol (~4%) of classical benchmarks" ← Classical computing got results close to classical computing. No surprise.
5th-paragraph says -- Just 8 qubits for 4 orbitals
"Promethium built and preprocessed a complex 115-atom model of the P450nor active site containing over 1,000 molecular orbitals. It automatically isolated the strongly correlated region down to a 4-orbital active space mapped onto 8 qubits, which IonQ Forte measured in a single basis before returning results for Promethium to compute final interaction energies classically."
↑ So this research artificially picked up only 4 orbitals as active space out of the original total 1000 molecular orbitals of a p450nor enzyme for just 8 useless ion qubits (= one qubit takes only 0 or 1 value, so still Not a quantum computer ). ↓
↑ Choosing just 4 orbitals cannot model the original bigger p450nor enzyme with more than 1000 orbitals, so No drug discovery
↑ And the useless IonQ's just 8 qubits were used for some measurement (= expressing the chosen 4 electrons' orbitals ) with No quantum computation. ← This molecular interaction energy for chosen 4 electrons' orbitals was calculated by a classical computer.
↑ This QC Ware overhyped research is useless, deadend with No progress from their past research ↓
↑ This-QC Ware's similar research in 2023 ↓
p.2-left-2nd-paragraph says
"Notably, NOR is a member of the cytochrome
P450 superfamily"
p.2-left-3rd-paragraph says -- Just 4 orbitals, 8 useless qubits
"In order to make our computations possible on today's quantum computers with limited qubit counts and
gate fidelities, we rely on classical quantum chemistry
methods to preprocess and heavily simplify the system.
Specifically, while we treated the studied molecules with
more than a thousand orbitals classically, we only utilize four orbitals (mapped to eight qubits)"
p.4-left-last-paragraph says -- Just 4 electrons cannot discover drugs
"To find the ground state energy in the active space, the
VQE algorithm is used. The fermionic Hamiltonian in
the (4e, 4o = 4 electrons in 4 orbitals ) active space is mapped.. onto a 8-qubit system,.. the first (last) 4 qubits are assigned
to the α/spin-up orbitals (β/spin-down orbitals) with a
qubit in state |1⟩/|0⟩ representing an occupied/unoccupied orbital." ↓
↑ This QC Ware research used just 8 useless ion qubits expressing the artificially-selected 4 orbitals (= 4 electros ) where each qubit 1 or 0 means each orbit is occupied or unoppupied by an electron with up or down spins with No quantum computation. ← Just 4 orbitals cannot express the original complicated p450 enzymes with more than 1000 orbitals.
↑ And they used the impractical hybrid VQE (= variational quantum eigensolver ) method which relied on a classical computer to calculate the molecular energy based on artificially chosen fake trial wavefunctions (= ansatz ) for unsolvable Schrodinger equation, which cannot predict anything nor discover drugs.
As a result, "Quantum computers calculating molecular energy for drug discovery !" is just an overhyped fake news.
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