(Fig.1) The present molecular machines are just overhyped useless science.
The present so-called "molecular machines" or "molecular motors" are just overhyped impractical things intended only for publishing papers in academic journals.
↑ Because really-useful molecular machines manipulating individual atoms should have been able to cure cancers and Alzheimer diseases, but the present science still cannot cure these serious diseases, so their molecular machines are Not really artificially-controllable molecular machines.
Researchers in the present molecular machines just conducted the ordinary ( old-fashioned ) macroscopic chemical and biological experiments (= mixing reagents, heating, cooling, centrifuge the whole solutions in beakers.. waiting for some desirable chemical reactions to luckily happen ).
Researchers ( in molecular machine field ) do Not look into individual atomic, molecular interactions nor manipulate individual atoms (= No atomic force nor scanning force microscopes to manipulate atoms are used in this molecular machine research ).
Because the present mainstream atomic physics or quantum mechanics is completely useless.
Only in some cases, researchers used the unphysical quantum mechanical one-pseudo-electron density functional theory (= DFT ) to vaguely estimate some total energies (= No prediction ).
This quantum mechanical DFT artificially chooses pseudo-potentials and exchange energy functionals with No ability to predict any physical values.
Furthermore, this unphysical DFT treating the whole material as one-pseudo-electron with fake mass can Not give concrete shapes to individual atoms or molecules.
So due to the quantum mechanical (or DFT ) unrealistic atoms with No shapes, researchers can Not use individual atoms with concrete shapes as practical tools to design or build really-useful molecular machines.
For example, in this overhyped news research, researchers stimulated some muscle cells with light, and observed the cell contraction without controlling individual molecules nor using (impractical) quantum mechanics.
↑ This research paper ↓
p.16-1st-paragraph says "cells were incubated with dyes and/or molecules resuspended in complete growth medium at the appropriate concentration MM 1 (8 µM), MM 2 .. (= These MM or so-called molecular machines are just some molecules changing their configuration by light, these MM molecules were synthesized by the ordinary macroscopic chemical experiments without manipulating individual atoms, this p.5-19 ).
p.15~p.21 Experimental methods do Not use any quantum mechanical methods such as Schrodinger equations, one-pseudo-electron DFT or molecular dynamics.
p.24-31 observed some cells' state change (= calcium density change ) after light absorption by fluorescent microscopes without looking into nor manipulating individual atoms.
↑ This p.7(or p.6)-2nd-paragraph says
"10,10-Dimethyl-9(10H)-anthracenone (1.67 g, 7.5 mmol) and Lawesson’s reagent (6.08 g, 15
mmol) were mixed in a solution of toluene (30 mL). The solution was heated to reflux for 14 h.
The solution was permitted to cool to room temperature. The toluene was removed by rotary
evaporation. The residue was purified by silica gel chromatography.." ← Old-fashioned macroscopic trial-and-error experiments without manipulating each single molecule.
This overhyped news research just moved some molecules a little by some chemical reaction in the normal macroscopic chemical experiment (= mixing reagents in beakers.. ) without controlling individual atoms.
↑ This research paper ↓
p.4-right-synthesis~p.5 conducted the ordinary macroscopic chemical experiments without manipulating individual atoms by atomic force microscopes.
p.10-Scheme.4 showed some oxidation slightly moved some molecules to right or left randomly (= without controlling the moving direction of individual molecules ).
p.11-12 conducted normal macroscopic chemical experiments without manipulating individual atoms nor using (impractical) quantum mechanics.
↑ This p.11-TTF derivative says
"2,6-Bis(2-cyanoethylthio)-3,7-
bis(methylthio)tetrathiafulvalene (212 mg, 0.454 mmol) was
dissolved in anhydrous THF (160 mL) and degassed (N2,
30 min). CsOH•H2O (77.5 mg, 0.461 mmol) was dissolved in
anhydrous MeOH (3.5 mL) and added dropwise over 90 min,
causing the initially orange solution to become dark red. After
1 h, 2-(2-(2-[4-(tris(4-t-butylphenyl)methyl)phenoxy]ethoxy)-
ethoxy)ethyliodide (317 mg, 0.424 mmol) was added. The
reaction mixture was stirred for 2 d before the solvent was
removed" ← Old-fashioned macroscopic trial-and-error experiments without manipulating each single molecule.
The 7th paragraph of this hyped news admits
" the current prototype is still far from being as efficient as the ribosome.."
↑ This research also just conducted ordinary macroscopic chemical experiments ( this p.6-45 ) without manipulating individual atoms, so Not real molecular machines.
↑ This p.8 says
"To a stirred solution of S1 (1.48 g, 6.5 mmol) in acetic acid at 0 °C was added dropwise
t-butyl nitrite (674 mg, 6.5 mmol). The reaction mixture was allowed to warm to room
temperature and after 30 min NaN3 (850 mg, 13.08 mmol) was added in small portions.
After a further 2 h stirring at room temperature the solvent was removed under reduced
pressure.." ← Old-fashioned macroscopic trial-and-error experiments without manipulating each single molecule.
And No quantum mechanical methods (= Schrodinger equations, DFT, MD.. ) were used.
This alleged artificial molecular machine research also just conducted macroscopic chemical experiments ( this p.7-17 ) without manipulating individual atoms.
↑ This research relies on the impractical one-pseudo-electron DFT model ( this or this p.4-Fig.4-12 ) lacking real atomic picture, which unrealistic quantum mechanical model cannot be used for manipulating individual atoms and building really-useful molecular machines.
This hyped news research also conducted only macroscopic chemical experiments without controlling individual atoms nor using (impractical) quantum mechanical methods ( this p.12-Experimental procedure-p.13 ).
This research (= p.8-left-quantum mechanical calculation ) used only one-pseudo-electron density functional theory (= DFT ) with empirical exchange energy (= M06-2X ) functional lacking real particle picture.
This p.5-12 used the ordinary macroscopic chemical experiments without manipulating individual atoms.
This research ( p.8-9-Experimental procedure ) used the ordinary macroscopic biological experiments without manipulating individual atoms nor using (impractical) quantum mechanics.
This research (= last paragraph ) used the impractical one-pseudo-electron DFT model and the ordinary macroscopic chemical reaction ( this p.4-6 ) without manipulating individual atoms.
So in the present researches on (hyped) molecular machines or molecular motors, researchers just conducted the ordinary ( old-fashioned ) macroscopic experiments without considering nor manipulating individual atoms (= by atomic force microscopes ) due to the impractical quantum mechanical (one-pseudo-electron DFT) model that hampers advance of science forever (= resultantly No cure for deadly diseases ).
2024/6/28 updated. Feel free to link to this site.
